Home The Road to Wellness The Role of the Essential Fatty Acids (Omega-3s) The Omega-6 Family and Prostaglandin 1 (PGE1) and Prostaglandin 2 (PGE2) Pathways
The Omega-6 Family and Prostaglandin 1 (PGE1) and Prostaglandin 2 (PGE2) Pathways PDF Print E-mail
The Role of the Essential Fatty Acids (Omega-3s)
  • The following figure shows the pathway of the Omega-6 (linoleic acid) fatty acid.
  • The first conversion is from (1) linoleic acid into (4) gamma linolenic acid. This is achieved through the action of the delta-6-desaturase enzyme (2).
  • Note that the delta-6-desaturase enzyme (2) is dependent upon sufficient quantities of vitamin B6, magnesium and zinc (3). 
  • Deficiencies in any of these three nutrients can impair the conversion.
  • Next is the conversion of gamma linolenic acid (4) into dihomogamma linolenic acid (6) by the enzyme elongase (5).
 
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